A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Comparison of Low-Gluten Diets Rich in Oats or Rice-A 6-Week Randomized Clinical Trial With Metabolically Challenged Volunteers
Tekijät: Mannila, Enni; Nuotio, Petrus; Kuosmanen, Anni; De Storvik, Suchetana; Kårlund, Anna; Jukkara, Aija; Tauriainen, Milla-Maria; Närväinen, Johanna; Kolehmainen, Marjukka; Linderborg, Kaisa M.
Kustantaja: WILEY
Kustannuspaikka: HOBOKEN
Julkaisuvuosi: 2025
Journal: Molecular Nutrition and Food Research
Tietokannassa oleva lehden nimi: MOLECULAR NUTRITION & FOOD RESEARCH
Lehden akronyymi: MOL NUTR FOOD RES
Artikkelin numero: e70076
Sivujen määrä: 16
ISSN: 1613-4125
eISSN: 1613-4133
DOI: https://doi.org/10.1002/mnfr.70076
Verkko-osoite: https://doi.org/10.1002/mnfr.70076
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/492143434
Low-gluten diets (LGD) are also widely followed by people not suffering from coeliac disease. This study compared oats and rice as the main cereal source of an LGD in metabolically challenged volunteers. Volunteers (n = 69) were randomly assigned to an LGD, which was either rich in oats or rice, for 6 weeks. Before and after the intervention, concentrations of total cholesterol, LDL-C, and HDL-C, triacylglycerols, free fatty acids, glucose, and insulin were measured from fasting plasma samples; the volunteers also completed 4-day food and stool records, as well as questionnaires related to perceived gastrointestinal discomfort (Gastrointestinal Symptom Rating Scale) and health (RAND-36). The intervention with oats resulted in a more substantial decrease in LDL-C (p(group x time) = 0.047), more frequently normal type stool (p(group x time) = 0.010), and bowel movements (p(group x time) = 0.038) than rice (group x time interaction). The rice group experienced more constipation symptoms (p(group x time) < 0.001) than the oat group, possibly due to a lower fiber intake (p(group x time) < 0.001). A greater waist circumference decrease was observed with rice than with oats (p(group x time) = 0.022). Our results suggest that oats improve both biochemical markers of cardiometabolic health and perceived gastrointestinal well-being compared to rice, thus being a crucial part of a nutritiously adequate LGD.
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Julkaisussa olevat rahoitustiedot:
The study was carried out with the financial support of the Finnish Cultural Foundation and the Finnish Foundation for Cardiovascular Research.Personal grants to Enni Mannila from the Raisio plc’s Research Foundation, Niemi Foundation, the Finnish Food Research Foundation, and the Graduate Schoolof the University of Turku are acknowledged.
