A1 Refereed original research article in a scientific journal
Short-term changes in inflammatory response protein (hsCRP) do not parallel with changes in coronary vasoreactivity in obese men
Authors: Sundell J, Laine H, Nuutila P, Luotolahti M, Knuuti J
Publisher: NATURE PUBLISHING GROUP
Publication year: 2006
Journal: International Journal of Obesity
Journal name in source: INTERNATIONAL JOURNAL OF OBESITY
Journal acronym: INT J OBESITY
Volume: 30
Issue: 3
First page : 460
Last page: 467
Number of pages: 8
ISSN: 0307-0565
DOI: https://doi.org/10.1038/sj.ijo.0803164
Abstract
Aim: Obese subjects are characterized by increased high-sensitivity C-reactive protein (hsCRP) and coronary vascular resistance. Clucocorticoids suppress inflammation, a possible cardioprotective effect. We tested the short-term anti-inflammatory effect of dexamethasone (dx) on these parameters in obese subjects.Methods: Coronary vascular resistance was quantitated basally and during adenosine infusion with or without simultaneous euglycemic hyperinsulinemic clamp (insulin infusion rate of 1 mU/kg/min) in 11 obese and 19 age-matched nonobese males using positron emission tomography and O-15-water. Each subject was studied both with and without previous dx treatment for 2 days (2 mg/day).Results: Before dx treatment, hsCRP concentration was significantly higher in obese than in nonobese subjects (1.55 +/- 1.73 vs 0.32 +/- 0.32 mg/l, P = 0.005). In addition, coronary vascular resistances were higher (P < 0.05) in obese than in nonobese subjects at baseline (139 +/- 36 vs 117 +/- 22) and during adenosine infusion without (32 +/- 7 vs 26 +/- 7) or with simultaneous clamp (26 +/- 8 vs 21 +/- 5 mmHg min g/ml). Dx treatment decreased significantly hsCRP concentration in obese but not in nonobese subjects, leading to similar hsCRP concentrations between the groups (0.45 +/- 0.43 vs 0.26 +/- 0.42 mg/l, respectively, P=0.3). Dx had no effect on coronary vascular resistances (NS).Conclusions: Obese subjects are characterized by high hsCRP, which can be normalized by dx. However, despite this, coronary vascular resistances did not decrease in obese subjects. Short-term changes in inflammatory response protein appear not to parallel with changes in coronary vasoreactivity in obese men.
Aim: Obese subjects are characterized by increased high-sensitivity C-reactive protein (hsCRP) and coronary vascular resistance. Clucocorticoids suppress inflammation, a possible cardioprotective effect. We tested the short-term anti-inflammatory effect of dexamethasone (dx) on these parameters in obese subjects.Methods: Coronary vascular resistance was quantitated basally and during adenosine infusion with or without simultaneous euglycemic hyperinsulinemic clamp (insulin infusion rate of 1 mU/kg/min) in 11 obese and 19 age-matched nonobese males using positron emission tomography and O-15-water. Each subject was studied both with and without previous dx treatment for 2 days (2 mg/day).Results: Before dx treatment, hsCRP concentration was significantly higher in obese than in nonobese subjects (1.55 +/- 1.73 vs 0.32 +/- 0.32 mg/l, P = 0.005). In addition, coronary vascular resistances were higher (P < 0.05) in obese than in nonobese subjects at baseline (139 +/- 36 vs 117 +/- 22) and during adenosine infusion without (32 +/- 7 vs 26 +/- 7) or with simultaneous clamp (26 +/- 8 vs 21 +/- 5 mmHg min g/ml). Dx treatment decreased significantly hsCRP concentration in obese but not in nonobese subjects, leading to similar hsCRP concentrations between the groups (0.45 +/- 0.43 vs 0.26 +/- 0.42 mg/l, respectively, P=0.3). Dx had no effect on coronary vascular resistances (NS).Conclusions: Obese subjects are characterized by high hsCRP, which can be normalized by dx. However, despite this, coronary vascular resistances did not decrease in obese subjects. Short-term changes in inflammatory response protein appear not to parallel with changes in coronary vasoreactivity in obese men.
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