A1 Refereed original research article in a scientific journal
Positron emission tomography - molecular imaging of biological processes
Authors: Knuuti J
Publication year: 2004
Journal: International Congress Series
Journal name in source: QUANTITATION IN BIOMEDICAL IMAGING WITH PET AND MRI
Journal acronym: INT CONGR SER
Issue: 1265
First page : 248
Last page: 254
Number of pages: 7
ISBN: 0-444-51567-4
ISSN: 0531-5131
DOI: https://doi.org/10.1016/j.ics.2004.06.014
Abstract
Positron emission tomography (PET) is an unsurpassed method for imaging human biochemical and physiological processes in vivo. Unlimited number of natural substrates, substrate analogs and drugs can be labeled for use with PET. This labeling does not change their chemical or biological properties. Minute amounts of biologically active compounds are labeled with positron emitting radionuclides and then administered to the subjects. The temporal and spatial distribution of these tracers within the body is measured with PET. PET combined with tracer kinetic models measures blood flow, membrane transport, metabolism, ligand-receptor interactions and recently also gene expression noninvasively and quantitatively in humans. PET has been used extensively to study cellular metabolism in the brain, heart and malignant tumors. (C) 2004 Published by Elsevier B.V.
Positron emission tomography (PET) is an unsurpassed method for imaging human biochemical and physiological processes in vivo. Unlimited number of natural substrates, substrate analogs and drugs can be labeled for use with PET. This labeling does not change their chemical or biological properties. Minute amounts of biologically active compounds are labeled with positron emitting radionuclides and then administered to the subjects. The temporal and spatial distribution of these tracers within the body is measured with PET. PET combined with tracer kinetic models measures blood flow, membrane transport, metabolism, ligand-receptor interactions and recently also gene expression noninvasively and quantitatively in humans. PET has been used extensively to study cellular metabolism in the brain, heart and malignant tumors. (C) 2004 Published by Elsevier B.V.
UTU Research Portal