A1 Refereed original research article in a scientific journal
Increased lipoprotein(a) is associated with reduced myocardial vasoreactivity in young healthy men
Authors: Sundell J, Laine H, Raitakari OT, Luotolahti M, Nuutila P, Viikari J, Knuuti J
Publisher: ELSEVIER SCI IRELAND LTD
Publication year: 2005
Journal: Atherosclerosis
Journal name in source: ATHEROSCLEROSIS
Journal acronym: ATHEROSCLEROSIS
Volume: 179
Issue: 1
First page : 185
Last page: 191
Number of pages: 7
ISSN: 0021-9150
DOI: https://doi.org/10.1016/j.atherosclerosis.2004.10.007
Abstract
Objectives and Background: We examined the association between lipoprotein(a) and myocardial vasoreactivity in healthy men.Methods: Thirty non-smoking healthy men (age 34 +/- 6 years) were studied: 9 had increased lipoprotein(a) (> 200mg/L) concentrations (lipoprotein(a) 317 (range 218-550)mg/L) and 21 had normal lipoprotein(a) (< 200mg/L) concentrations (lipoprotein(a) 57 (range 13-156) mg/L). The myocardial blood flow measurements were performed basally and during adenosine infusion (140 mu g/kg/min) with or without simultaneous physiological hyperinsulinemia (insulin infusion at a rate of 1 mU/kg/min) using positron emission tomography and [O-15]H2O.Results: Basal myocardial blood flow was similar between the subjects with increased and normal lipoprotein(a) (0.76 +/- 0.20 and 0.79 +/- 0.20 mL g(-1) min(-1), NS). Adenosine-stimulated flow tended to be reduced in subjects with increased lipoprotein(a) (3.1 +/- 0.7 mL g(-1) min(-1) versus 3.7 +/- 1.1 mL g(-1) min(-1) respectively, p=0.1). During physiological hyperinsulinemia adenosine-stimulated flow was further enhanced in both groups but significantly blunted in subjects with increased lipoprotein(a) (3.7 +/- 0.8 mL g(-1) min(-1) versus 4.8 +/- 1.4 mL g(-1) min(-1) respectively, p=0.03). This difference remained significant after simultaneous controlling for BMI, HbAlc, LDL-cholesterol, HDL-cholesterol and blood pressure (P = 0.04).Conclusions: Already young healthy men with lipoprotein(a) concentrations greater than 200 mg/L are characterized by impaired myocardial vasoreactivity. (c) 2004 Elsevier Ireland Ltd. All rights reserved.
Objectives and Background: We examined the association between lipoprotein(a) and myocardial vasoreactivity in healthy men.Methods: Thirty non-smoking healthy men (age 34 +/- 6 years) were studied: 9 had increased lipoprotein(a) (> 200mg/L) concentrations (lipoprotein(a) 317 (range 218-550)mg/L) and 21 had normal lipoprotein(a) (< 200mg/L) concentrations (lipoprotein(a) 57 (range 13-156) mg/L). The myocardial blood flow measurements were performed basally and during adenosine infusion (140 mu g/kg/min) with or without simultaneous physiological hyperinsulinemia (insulin infusion at a rate of 1 mU/kg/min) using positron emission tomography and [O-15]H2O.Results: Basal myocardial blood flow was similar between the subjects with increased and normal lipoprotein(a) (0.76 +/- 0.20 and 0.79 +/- 0.20 mL g(-1) min(-1), NS). Adenosine-stimulated flow tended to be reduced in subjects with increased lipoprotein(a) (3.1 +/- 0.7 mL g(-1) min(-1) versus 3.7 +/- 1.1 mL g(-1) min(-1) respectively, p=0.1). During physiological hyperinsulinemia adenosine-stimulated flow was further enhanced in both groups but significantly blunted in subjects with increased lipoprotein(a) (3.7 +/- 0.8 mL g(-1) min(-1) versus 4.8 +/- 1.4 mL g(-1) min(-1) respectively, p=0.03). This difference remained significant after simultaneous controlling for BMI, HbAlc, LDL-cholesterol, HDL-cholesterol and blood pressure (P = 0.04).Conclusions: Already young healthy men with lipoprotein(a) concentrations greater than 200 mg/L are characterized by impaired myocardial vasoreactivity. (c) 2004 Elsevier Ireland Ltd. All rights reserved.
UTU Research Portal