A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Angiotensin-converting enzyme gene polymorphism and coronary reactivity in young men
Tekijät: Kahonen M, Lehtimaki T, Laaksonen R, Janatuinen T, Vesalainen R, Laine H, Raitakari OT, Nuutila P, Knuuti J, Nieminen T
Kustantaja: TAYLOR & FRANCIS LTD
Julkaisuvuosi: 2007
Journal: Scandinavian Journal of Clinical and Laboratory Investigation
Tietokannassa oleva lehden nimi: SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION
Lehden akronyymi: SCAND J CLIN LAB INV
Vuosikerta: 67
Numero: 6
Aloitussivu: 596
Lopetussivu: 603
Sivujen määrä: 8
ISSN: 0036-5513
DOI: https://doi.org/10.1080/00365510701213461
Tiivistelmä
The purpose of the study was to examine whether the insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE) gene affects the vasodilatory properties of coronary arteries in healthy men. The ACE genotypes of 128 men (mean age 35 +/- 4 years) were determined and related to myocardial blood flow. The blood flow was measured by positron emission tomography at rest and during vasodilation caused by adenosine or dipyridamole infusion. The coronary flows and resistances at rest and during stimulation with adenosine or dipyridamole did not differ between the ACE genotypes. Furthermore, this polymorphism had no effect on coronary flow reserve corrected by a rate-pressure product. In conclusion, the ACE I/D polymorphism does not seem to affect myocardial reactivity-an early indicator of atherosclerosis-in healthy subjects.
The purpose of the study was to examine whether the insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE) gene affects the vasodilatory properties of coronary arteries in healthy men. The ACE genotypes of 128 men (mean age 35 +/- 4 years) were determined and related to myocardial blood flow. The blood flow was measured by positron emission tomography at rest and during vasodilation caused by adenosine or dipyridamole infusion. The coronary flows and resistances at rest and during stimulation with adenosine or dipyridamole did not differ between the ACE genotypes. Furthermore, this polymorphism had no effect on coronary flow reserve corrected by a rate-pressure product. In conclusion, the ACE I/D polymorphism does not seem to affect myocardial reactivity-an early indicator of atherosclerosis-in healthy subjects.
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