A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä

IL17Frs763780 single nucleotide polymorphism is associated with asthma after bronchiolitis in infancy




TekijätHolster Annukka, Teräsjärvi Johanna, Barkoff Alex-Mikael, Lauhkonen Eero, Törmanen Sari, Helminen Merja, Korppi Matti, He Qiushui, Nuolivirta Kirsi

KustantajaWILEY

Julkaisuvuosi2021

JournalActa Paediatrica

Tietokannassa oleva lehden nimiACTA PAEDIATRICA

Lehden akronyymiACTA PAEDIATR

Vuosikerta110

Numero1

Aloitussivu222

Lopetussivu227

Sivujen määrä6

ISSN0803-5253

eISSN1651-2227

DOIhttps://doi.org/10.1111/apa.15390

Verkko-osoitehttps://onlinelibrary.wiley.com/doi/full/10.1111/apa.15390


Tiivistelmä

Aim

Interleukin-17F (IL-17F) is involved with asthma. The aim of this study was to evaluate the association of IL17F polymorphisms with childhood asthma after bronchiolitis in infancy.

Methods

We invited 166 children who were hospitalised for bronchiolitis at younger than 6 months of age to follow-up visits at 5-7 years and 11-13 years of ages. Asthma and allergy diagnoses, asthma-presumptive symptoms and use of inhaled corticosteroids (ICSs) were registered. Blood samples were available for IL17F rs763780 (T/C), rs11465553 (C/T) and rs7741835 (C/T) determinations in 165 cases.

Results

The presence of IL17F rs11465553 and rs7741835 variations showed no significant associations with any asthma or allergy outcome at either 5-7 years or 11-13 years of ages. Instead, children with the variant IL17F rs763780 genotype had used more often ICSs between the follow-up visits from 5-7 to 11-13 years (adjusted OR 3.58) than those with the wild genotype. Children with the variant IL17F rs763780 genotype reported more often doctor-diagnosed atopic dermatitis (adjusted OR 2.71) at 11-13 years of age than those with the wild genotype.

Conclusion

This prospective long-term follow-up study provided preliminary evidence on the association of the IL17F rs763780 polymorphism with asthma at school age after bronchiolitis in infancy.



Last updated on 2024-26-11 at 12:50