Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1)

IL17Frs763780 single nucleotide polymorphism is associated with asthma after bronchiolitis in infancy




Julkaisun tekijät: Holster Annukka, Teräsjärvi Johanna, Barkoff Alex-Mikael, Lauhkonen Eero, Törmanen Sari, Helminen Merja, Korppi Matti, He Qiushui, Nuolivirta Kirsi

Kustantaja: WILEY

Julkaisuvuosi: 2021

Journal: Acta Paediatrica

Tietokannassa oleva lehden nimi: ACTA PAEDIATRICA

Lehden akronyymi: ACTA PAEDIATR

Volyymi: 110

Julkaisunumero: 1

Sivujen määrä: 6

ISSN: 0803-5253

eISSN: 1651-2227

DOI: http://dx.doi.org/10.1111/apa.15390

Verkko-osoite: https://onlinelibrary.wiley.com/doi/full/10.1111/apa.15390


Tiivistelmä

Aim

Interleukin-17F (IL-17F) is involved with asthma. The aim of this study was to evaluate the association of IL17F polymorphisms with childhood asthma after bronchiolitis in infancy.

Methods

We invited 166 children who were hospitalised for bronchiolitis at younger than 6 months of age to follow-up visits at 5-7 years and 11-13 years of ages. Asthma and allergy diagnoses, asthma-presumptive symptoms and use of inhaled corticosteroids (ICSs) were registered. Blood samples were available for IL17F rs763780 (T/C), rs11465553 (C/T) and rs7741835 (C/T) determinations in 165 cases.

Results

The presence of IL17F rs11465553 and rs7741835 variations showed no significant associations with any asthma or allergy outcome at either 5-7 years or 11-13 years of ages. Instead, children with the variant IL17F rs763780 genotype had used more often ICSs between the follow-up visits from 5-7 to 11-13 years (adjusted OR 3.58) than those with the wild genotype. Children with the variant IL17F rs763780 genotype reported more often doctor-diagnosed atopic dermatitis (adjusted OR 2.71) at 11-13 years of age than those with the wild genotype.

Conclusion

This prospective long-term follow-up study provided preliminary evidence on the association of the IL17F rs763780 polymorphism with asthma at school age after bronchiolitis in infancy.


Last updated on 2022-29-09 at 09:37