Characterization of myocardial oxidative metabolism and myocardial external efficiency in high-risk alcohol cardiotoxicity and alcoholic cardiomyopathy via dynamic(11)C-Acetate positron emission tomography

: Ximin Shi, Shuai Liu, Xue Lin, Xihai Zhao, Ligang Fang, Jie Ding, Yonghong Dang, Haiqun Xing, Chunlei Han, Chengyan Dong, Bailing Hsu, Wei Fang, Fang Li, Li Huo, Juhani Knuuti

Publisher: SPRINGER

: 2020

: Journal of Nuclear Cardiology

: JOURNAL OF NUCLEAR CARDIOLOGY

: J NUCL CARDIOL

: 29

: 1

: 278

: 288

: 11

: 1071-3581

: 1532-6551

DOI: https://doi.org/10.1007/s12350-020-02214-0

Introduction The purpose of this study was to evaluate subjects with high-risk alcohol cardiotoxicity and patients with alcoholic cardiomyopathy (ACM) via dynamic(11)C-Acetate positron emission tomography (PET) imaging as a myocardial oxidative metabolic probe. Methods and Results We recruited 37 subjects with chronic alcohol consumption [18 with moderate consumption (MC), 19 with heavy consumption (HC)], 5 ACM patients, and 12 healthy controls to receive dynamic(11)C-Acetate PET scans. PET imaging data were analyzed to calculate kinetic parameters (e.g.,K-mono,K(1)andk(2)) based on the mono-exponential and one-tissue compartmental models. Myocardial oxygen consumption (MVO2) and myocardial external efficiency (MEE) were then derived from these kinetic parameters. MVO(2)was significantly lowered in the HC group and in ACM patients (0.121 +/- 0.018 and 0.111 +/- 0.017 mL center dot g(-1)center dot min(-1), respectively) compared with those in healthy controls and MC subjects (0.144 +/- 0.023 and 0.146 +/- 0.027 mL center dot g(-1)center dot min(-1), respectively;P< .01). MEE was significantly reduced in ACM patients (13.0% +/- 4.3%) compared with those of healthy controls (22.4% +/- 4.6%,P< .01), MC subjects (20.1% +/- 4.5%,P< .05), and HC subjects (22.3% +/- 4.5%,P< .001). Conclusion Functional assessment via dynamic(11)C-Acetate PET imaging may represent a clinically feasible probe for identifying cohorts with high-risk cardiotoxicity due to addictive alcohol consumption and ACM.