A2 Review article in a scientific journal

Kinase-Independent Functions of MASTL in Cancer: A New Perspective on MASTL Targeting

List of Authors: James Ronald William Conway, Elisa Närvä, Maria Emilia Taskinen, Johanna Ivaska

Publisher: MDPI

Publication year: 2020

Journal: Cells

Volume number: 9

Issue number: 7

Number of pages: 11

eISSN: 2073-4409

DOI: http://dx.doi.org/10.3390/cells9071624


Microtubule-associated serine/threonine kinase-like (MASTL; Greatwall)
is a well-characterized kinase, whose catalytic role has been
extensively studied in relation to cell-cycle acceleration. Importantly,
MASTL has been implicated to play a substantial role in cancer
progression and subsequent studies have shown that MASTL is a
significant regulator of the cellular actomyosin cytoskeleton. Several
kinases have non-catalytic properties, which are essential or even
sufficient for their functions. Likewise, MASTL functions have been
attributed both to kinase-dependent phosphorylation of downstream
substrates, but also to kinase-independent regulation of the actomyosin
contractile machinery. In this review, we aimed to highlight the
catalytic and non-catalytic roles of MASTL in proliferation, migration,
and invasion. Further, we discussed the implications of this dual role
for therapeutic design.

Downloadable publication

This is an electronic reprint of the original article.
This reprint may differ from the original in pagination and typographic detail. Please cite the original version.

Last updated on 2021-24-06 at 09:56