A1 Journal article – refereed

Zinc acetate lozenges for the treatment of the common cold: a randomised controlled trial




List of Authors: Harri Hemilä, Jari Haukka, Marianne Alho, Jussi Vahtera, Mika Kivimäki

Publisher: BMJ PUBLISHING GROUP

Publication year: 2020

Journal: BMJ Open

Journal name in source: BMJ OPEN

Journal acronym: BMJ OPEN

Volume number: 10

Issue number: 1

Number of pages: 8

ISSN: 2044-6055

eISSN: 2044-6055

DOI: http://dx.doi.org/10.1136/bmjopen-2019-031662


Abstract
ObjectiveTo examine a commercially available zinc acetate lozenge for treating the common cold.DesignRandomised, double-blinded, placebo-controlled trial.SettingWorking population in Finland.ParticipantsWe included men and women aged >= 18 years who usually had >= 1 cold per winter. Exclusions were pregnancy, lactation, chronic runny nose or chronic cough.InterventionWe randomised 253 participants to receive a package of lozenges to be taken if they caught the common cold. Of the 253 participants, 88 contracted the common cold and 87 were included in our primary analysis. Zinc acetate lozenges contained 13 mg elemental zinc and placebo lozenges contained sucrose octa-acetate to camouflage the taste of zinc. Instruction to use was six times per day for the maximum of 5 days.Primary outcomeRate of recovery from the common cold analysed by Cox regression.ResultsThere was no difference in the recovery rate between zinc and placebo participants during the 10-day follow-up (rate ratio for zinc vs placebo=0.68, 95% CI 0.42 to 1.08; p=0.10). The recovery rate for the two groups was similar during the 5-day intervention, but for 2 days after the end of zinc/placebo use, the zinc participants recovered significantly slower compared with the placebo participants (p=0.003). In the zinc group, 37% did not report adverse effects, the corresponding proportion being 69% in the placebo group.ConclusionsA commercially available zinc acetate lozenge was not effective in treating the common cold when instructed to be used for 5 days after the first symptoms. Taste has been a common problem in previous zinc lozenge trials, but a third of zinc participants did not complain of any adverse effects. More research is needed to evaluate the characteristics of zinc lozenges that may be clinically efficacious before zinc lozenges can be widely promoted for common cold treatment.

Downloadable publication

This is an electronic reprint of the original article.
This reprint may differ from the original in pagination and typographic detail. Please cite the original version.




Last updated on 2021-24-06 at 08:07