A1 Refereed original research article in a scientific journal
Plasma level of interleukin-18 and complicated course of febrile neutropenia in hematological patients after intensive chemotherapy
Authors: Korpelainen S, Hämäläinen S, Vänskä M, Koivula I, Pulkki K, Jantunen E, Juutilainen A, Purhonen AK
Publisher: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
Publication year: 2020
Journal: Cytokine
Journal name in source: CYTOKINE
Journal acronym: CYTOKINE
Article number: ARTN 155021
Volume: 129
Number of pages: 4
ISSN: 1043-4666
eISSN: 1096-0023
DOI: https://doi.org/10.1016/j.cyto.2020.155021
Abstract
In search of a biomarker for complicated course of febrile neutropenia (FN), plasma IL-18 was measured in 92 hematological patients after intensive chemotherapy at the beginning of FN (days 0-3). Complicated course was defined as blood culture positivity or septic shock. IL-18 varied according to background hematological malignancy and showed an inverse correlation with leukocyte count. IL-18 was not associated with complicated course of FN, defined as blood culture positivity or septic shock, in the whole study group, but an association was observed on d1 and d2 after the onset of FN in the subgroup of autologous stem cell transplant recipients with non-Hodgkin lymphoma.
In search of a biomarker for complicated course of febrile neutropenia (FN), plasma IL-18 was measured in 92 hematological patients after intensive chemotherapy at the beginning of FN (days 0-3). Complicated course was defined as blood culture positivity or septic shock. IL-18 varied according to background hematological malignancy and showed an inverse correlation with leukocyte count. IL-18 was not associated with complicated course of FN, defined as blood culture positivity or septic shock, in the whole study group, but an association was observed on d1 and d2 after the onset of FN in the subgroup of autologous stem cell transplant recipients with non-Hodgkin lymphoma.
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