A2 Review article in a scientific journal

Human papillomavirus prevalence in oral potentially malignant disorders: Systematic review and meta-analysis

List of Authors: de la Cour Cecilie D, Sperling Cecilie D, Belmonte Federica, Syrjänen Stina, Kjaer Susanne K

Publisher: WILEY

Publication year: 2021

Journal: Oral Diseases

Journal name in source: ORAL DISEASES

Journal acronym: ORAL DIS

Volume number: 27

Issue number: 3

Number of pages: 8

ISSN: 1354-523X

eISSN: 1601-0825

DOI: http://dx.doi.org/10.1111/odi.13322

Objectives: We aimed to provide pooled estimates of human papillomavirus (HPV) prevalence in oral potentially malignant disorders (OPMD) and evaluate the impact of presence of epithelial dysplasia.Methods: We searched PubMed, Embase, and Cochrane Library databases for studies that examined the prevalence of HPV DNA in OPMD tested by polymerase chain reaction (PCR).Results: Across 52 eligible studies (2,677 cases), we found an overall pooled HPV prevalence of 22.5% (95% confidence interval [CI] 16.6-29.0). Between-study heterogeneity was 93%. When stratified by subgroup, the pooled HPV prevalence in leukoplakia (1,232 cases) was 20.2% (95% CI 11.2-31.1), lichen planus (767 cases) 23.0% (95% CI 15.0-32.2), oral submucous fibrosis (238 cases) 28.6% (95% CI 23.0-34.5), proliferative verrucous leukoplakia (60 cases) 24.7% (95% CI 1.8-62.0), and OPMD unspecified (377 cases) 25.4% (95% CI 16.2-35.8). Information on presence of epithelial dysplasia was available in 19 studies, and the results did not vary substantially between non-dysplastic and dysplastic samples. HPV16 was the predominant genotype among HPV-positive OPMD cases (48.2%, 95% CI 31.4-65.2).Conclusion: We found a pooled HPV DNA prevalence of 22.5% in OPMD cases with great between-study heterogeneity. The HPV prevalence appeared to be comparable across subgroups and independent of epithelial dysplasia.

Last updated on 2021-07-09 at 13:40