Refereed review article in scientific journal (A2)
15O-Water PET MPI: Current Status and Future Perspectives
List of Authors: Maaniitty T, Knuuti J, Saraste A
Publisher: W B SAUNDERS CO-ELSEVIER INC
Publication year: 2020
Journal: Seminars in Nuclear Medicine
Journal name in source: SEMINARS IN NUCLEAR MEDICINE
Journal acronym: SEMIN NUCL MED
Volume number: 50
Issue number: 3
Start page: 238
End page: 247
Number of pages: 10
ISSN: 0001-2998
DOI: http://dx.doi.org/10.1053/j.semnuclmed.2020.02.011
Abstract
Myocardial perfusion imaging with 15O-water positron emission tomography (PET) is a validated tool for quantitative measurement of myocardial blood flow (MBF) and myocardial flow reserve (MFR). Current scanner and software technology enable quantification of global and regional MBF in clinical PET myocardial perfusion imaging studies. Reduced stress MBF or MFR measured by 15O-water PET accurately detects hemodynamically significant coronary artery stenosis defined by intracoronary fractional flow reserve (FFR) measurement in patients with suspected obstructive coronary artery disease (CAD). Furthermore, MBF and MFR provide prognostic information on mortality and risk of myocardial infarction. Clinical experience in some centers indicates that clinical application of 15O-water PET in evaluation of CAD is feasible and guides management decisions on revascularization. This review discusses basic concepts of measuring MBF with 15O-water PET and reviews clinical studies on its application in evaluation of obstructive CAD. (C) 2020 Elsevier Inc. All rights reserved.
Myocardial perfusion imaging with 15O-water positron emission tomography (PET) is a validated tool for quantitative measurement of myocardial blood flow (MBF) and myocardial flow reserve (MFR). Current scanner and software technology enable quantification of global and regional MBF in clinical PET myocardial perfusion imaging studies. Reduced stress MBF or MFR measured by 15O-water PET accurately detects hemodynamically significant coronary artery stenosis defined by intracoronary fractional flow reserve (FFR) measurement in patients with suspected obstructive coronary artery disease (CAD). Furthermore, MBF and MFR provide prognostic information on mortality and risk of myocardial infarction. Clinical experience in some centers indicates that clinical application of 15O-water PET in evaluation of CAD is feasible and guides management decisions on revascularization. This review discusses basic concepts of measuring MBF with 15O-water PET and reviews clinical studies on its application in evaluation of obstructive CAD. (C) 2020 Elsevier Inc. All rights reserved.
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