Drug reaction with eosinophilia and systemic symptoms after ocrelizumab therapy



: Marjo Nylund, Tytti Vuorinen, Laura Airas

Publisher: Elsevier

: 2020

: Multiple Sclerosis and Related Disorders

: Multiple sclerosis and related disorders

: Mult Scler Relat Disord

: 102058

: 42

: 3

: 2211-0348

: 2211-0356

DOI: https://doi.org/10.1016/j.msard.2020.102058


We report here on a young woman with multiple sclerosis, who developed a condition with eosinophilia and swelling of limbs seven weeks after initiation of ocrelizumab treatment. We consider her drug reaction to be compatible with a drug reaction with eosinophilia and systemic symptoms (DRESS), also called drug-induced hypersensitivity syndrome. She was treated with antihistamine and corticosteroid treatments, and recovered fully within three months of symptom onset. Ocrelizumab was not re-initiated. We are not aware of other DRESS-like cases related to ocrelizumab treatment.



Last updated on 2024-26-11 at 22:33