A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Early childhood and adolescent risk factors for psychotic depression in a general population birth cohort sample
Tekijät: Nietola M, Huovinen H, Heiskala A, Nordström T, Miettunen J, Korkeila J, Jääskeläinen E
Kustantaja: SPRINGER HEIDELBERG
Julkaisuvuosi: 2020
Journal: Social Psychiatry and Psychiatric Epidemiology
Tietokannassa oleva lehden nimi: SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
Lehden akronyymi: SOC PSYCH PSYCH EPID
Vuosikerta: 55
Aloitussivu: 1179
Lopetussivu: 1186
Sivujen määrä: 8
ISSN: 0933-7954
eISSN: 1433-9285
DOI: https://doi.org/10.1007/s00127-020-01835-7
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/46361735
Background and purpose In the group of severe mental disorders, psychotic depression (PD) is essentially under-researched. Knowledge about the risk factors is scarce and this applies especially to early risk factors. Our aim was to study early childhood and adolescent risk factors of PD in a representative birth cohort sample with a follow-up of up to 50 years. Methods The study was carried out using the Northern Finland Birth Cohort 1966 (NFBC 1966). We used non-psychotic depression (NPD) (n = 746), schizophrenia (SZ) (n = 195), psychotic bipolar disorder (PBD) (n = 27), other psychoses (PNOS) (n = 136) and healthy controls (HC) (n = 8200) as comparison groups for PD (n = 58). We analysed several potential early risk factors from time of birth until the age of 16 years. Results The main finding was that parents' psychiatric illness [HR 3.59 (1.84-7.04)] was a risk factor and a high sports grade in school was a protective factor [HR 0.29 (0.11-0.73)] for PD also after adjusting for covariates in the multivariate Cox regression model. Parental psychotic illness was an especially strong risk factor for PD. The PD subjects had a parent with psychiatric illness significantly more often (p < 0.05) than NPD subjects. Differences between PD and other disorder groups were otherwise small. Conclusions A low sports grade in school may be a risk factor for PD. Psychiatric illnesses, especially psychoses, are common in the parents of PD subjects. A surprisingly low number of statistically significant risk factors may have resulted from the size of the PD sample and the underlying heterogeneity of the etiology of PD.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
