A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Green and controllable synthesis of symmetrical and unsymmetrical difluoromethylated diarylmethanes via a direct bisarylation strategy enabled by an HFIP-B(C6F5)3 adduct
Tekijät: Li, Xindi; Zhu, Yiping; Gong, Zhina; Li, Jinshan; Xie, Jialin; Zhao, Zhendong; Li, Jianwei; Jia, Chunman
Kustantaja: ROYAL SOC CHEMISTRY
Kustannuspaikka: CAMBRIDGE
Julkaisuvuosi: 2024
Journal: Green Chemistry
Tietokannassa oleva lehden nimi: GREEN CHEMISTRY
Lehden akronyymi: GREEN CHEM
Vuosikerta: 26
Numero: 21
Aloitussivu: 10969
Lopetussivu: 10974
Sivujen määrä: 6
ISSN: 1463-9262
eISSN: 1463-9270
DOI: https://doi.org/10.1039/d4gc03917c
Verkko-osoite: https://doi.org/10.1039/D4GC03917C
A metal-free B(C6F5)(3) and HFIP synergistically catalyzed bisarylation reaction between difluoroacetaldehyde ethyl hemiacetal and anilines was developed to efficiently synthesize symmetrical and unsymmetrical difluoromethylated diarylmethanes without using stoichiometric activating agents or in concentrated strong acid media. This efficient, scalable and operationally simple protocol displays high atom economy and broad substrate tolerance, allowing quick access to diverse symmetrical and unsymmetrical difluoromethylated diarylmethane products under mild conditions. Furthermore, the recyclability and reusability of the HFIP solvent make the reaction environmentally friendly.
Julkaisussa olevat rahoitustiedot:
We are grateful for the financial support from the National Natural Science Foundation of China (22161017 and 22161016), Innovational Fund for Scientific and Technological Personnel of Hainan Province (KJRC2023D34) and the Start-up Research Foundation of Hainan University (KYQD(ZR)23166).
