B3 Non-refereed article in a conference publication

The response of phagocytes to indoor air toxicity




AuthorsL. Vilén, J. Atosuo, E. Suominen, E.-M. Lilius

EditorsPedro M. Arezes, João Santos Baptista, Monica P. Barroso, Paula Carneiro, Patrício Cordeiro, Nelson Costa, Rui B. Melo, A. Sergio Miguel, Gonçalo Perestrelo

Conference nameInternational Symposium on Occupation Safety and Hygiene

PublisherCRC PRESS-BALKEMA, PO BOX 11320, LEIDEN, 2301 EH, NETHERLANDS

Publication year2018

Book title Occupational Safety and Hygiene VI

Journal name in sourceOCCUPATIONAL SAFETY AND HYGIENE VI

First page 341

Last page345

Number of pages5

ISBN978-1-138-54203-7

eISBN978-1-351-00888-4

DOIhttps://doi.org/10.1201/9781351008884(external)


Abstract
This Perspective presents a viewpoint on potential methods assessing toxicity of indoor air. Until recently, the major techniques to document mouldy environment have been microbial isolation using conventional culture techniques for fungi and bacteria as well as in some instances polymerase chain reaction to detect microbial genetic components. It has become increasingly evident that bacterial and fungal toxins, their metabolic products and volatile organic substances emitted from corrupted constructions are the major health risks. Here, we illustrate how phagocytes, especially neutrophils can be used either in vitro as probe cells, directly exposed to the toxic agent studied, or they can act as in vivo indicators of the whole biological system exposed to the agent. There are two convenient methods assessing the responses: to measure chemiluminescence emission from activated phagocytes and to measure quantitatively by flow cytometry the expression of complement and immunoglobulin receptors on the phagocyte surface.



Last updated on 2024-26-11 at 23:12