A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Metabolically Healthy Obesity and High Carotid Intima-Media Thickness in Children and Adolescents: International Childhood Vascular Structure Evaluation Consortium
Tekijät: Min Zhao, Abel López-Bermejo, Carmelo A. Caserta, Carla Campos Muniz Medeiros, Anastasios Kollias, Judit Bassols,
Elisabetta L. Romeo, Thacira Dantas Almeida Ramos, George S. Stergiou, Lili Yang, Silvia Xargay-Torrent, Angela Amante,Tatianne Moura Estrela Gusmão, Evangelos Grammatikos, Yuanyuan Zhang, Anna Prats-Puig, Danielle Franklin de Carvalho, Liu Yang, Gemma Carreras-Badosa, Mônica de Oliveira Simões, Yaping Hou, Berta Mas-Pares,Wang Shui, Teng Guo, Mingming Wang, Hua Chen, Xiaohuan Lou, Qian Zhang, Yanqing Zhang, Pascal Bovet, Costan G. Magnussen, Bo Xi and Structure Evaluation Consortium
Kustantaja: AMER DIABETES ASSOC
Julkaisuvuosi: 2019
Journal: Diabetes Care
Tietokannassa oleva lehden nimi: DIABETES CARE
Lehden akronyymi: DIABETES CARE
Vuosikerta: 42
Numero: 1
Aloitussivu: 119
Lopetussivu: 125
Sivujen määrä: 7
ISSN: 0149-5992
DOI: https://doi.org/10.2337/dc18-1536
OBJECTIVE
It has been argued that metabolically healthy obesity (MHO) does not increase cardiovascular disease (CVD) risk. This study examines the association of MHO with carotid intima-media thickness (cIMT), a proxy of CVD risk, in children and adolescents.
RESEARCH DESIGN AND METHODS
Data were available for 3,497 children and adolescents aged 6-17 years from five population-based cross-sectional studies in Brazil, China, Greece, Italy, and Spain. Weight status categories (normal, overweight, and obese) were defined using BMI cutoffs from the International Obesity Task Force. Metabolic status (defined as "healthy" [no risk factors] or "unhealthy" [one or more risk factors]) was based on four CVD risk factors: elevated blood pressure, elevated triglyceride levels, reduced HDL cholesterol, and elevated fasting glucose. High cIMT was defined as cIMT >= 90th percentile for sex, age, and study population. Logistic regression model was used to examine the association of weight and metabolic status with high cIMT, with adjustment for sex, age, race/ethnicity, and study center.
RESULTS
In comparison with metabolically healthy normal weight, odds ratios (ORs) for high cIMT were 2.29 (95% CI 1.58-3.32) for metabolically healthy overweight and 3.91 (2.46-6.21) for MHO. ORs for high cIMT were 1.44 (1.03-2.02) for unhealthy normal weight, 3.49 (2.51-4.85) for unhealthy overweight, and 6.96 (5.05-9.61) for unhealthy obesity.
CONCLUSIONS
Among children and adolescents, cIMT was higher for both MHO and metabolically healthy overweight compared with metabolically healthy normal weight. Our findings reinforce the need for weight control in children and adolescents irrespective of their metabolic status.
