A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä
Renin-angiotensin-system, a potential pharmacological candidate, in acute respiratory distress syndrome during mechanical ventilation
Tekijät: Di Wang, Xiao-qing Chai, Costan G. Magnussen, Graeme R. Zosky, Shu-hua Shu, Xin Wei, Shan-shan Hu
Kustantaja: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
Julkaisuvuosi: 2019
Journal: Pulmonary Pharmacology and Therapeutics
Tietokannassa oleva lehden nimi: PULMONARY PHARMACOLOGY & THERAPEUTICS
Lehden akronyymi: PULM PHARMACOL THER
Artikkelin numero: ARTN 101833
Vuosikerta: 58
Sivujen määrä: 6
ISSN: 1094-5539
eISSN: 1522-9629
DOI: https://doi.org/10.1016/j.pupt.2019.101833
Tiivistelmä
While effective treatments for acute respiratory distress syndrome (ARDS) are lacking, mechanical lung ventilation can sustain adequate gas exchange in critically ill patients with respiratory failure due to ARDS. However, as a result of the phenomenon of ventilator-induced lung injury (VILI), there is an increasing need to seek beneficial pharmacological therapies for ARDS. Recent studies have suggested the renin-angiotensin system (RAS), which consists of the ACE/Ang-II/AT1R axis and ACE2/Ang-(1-7)/MasR axis, plays a dual role in the pathogenesis of ARDS and VILI. This review highlights the deleterious action of ACE/Ang-II/AT1R axis and the beneficial role of ACE2/Ang-(1-7)/MasR axis, as well as AT2R, in VILI and ARDS, and also discusses the possibility of targeting RAS components with pharmacological interventions to improve outcomes in ARDS.
While effective treatments for acute respiratory distress syndrome (ARDS) are lacking, mechanical lung ventilation can sustain adequate gas exchange in critically ill patients with respiratory failure due to ARDS. However, as a result of the phenomenon of ventilator-induced lung injury (VILI), there is an increasing need to seek beneficial pharmacological therapies for ARDS. Recent studies have suggested the renin-angiotensin system (RAS), which consists of the ACE/Ang-II/AT1R axis and ACE2/Ang-(1-7)/MasR axis, plays a dual role in the pathogenesis of ARDS and VILI. This review highlights the deleterious action of ACE/Ang-II/AT1R axis and the beneficial role of ACE2/Ang-(1-7)/MasR axis, as well as AT2R, in VILI and ARDS, and also discusses the possibility of targeting RAS components with pharmacological interventions to improve outcomes in ARDS.
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