A4 Refereed article in a conference publication
The Effect of Tissue Physiological Variability on Transurethral Ultrasound Therapy of the Prostate
Authors: Suomi V, Treeby B, Jaros J, Saunavaara J, Kiviniemi A, Blanco R
Conference name: Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
Publication year: 2018
Journal: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Book title : 2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
Journal name in source: Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
Journal acronym: Conf Proc IEEE Eng Med Biol Soc
Volume: 2018
First page : 5701
Last page: 5704
ISBN: 978-1-5386-3647-3
ISSN: 1557-170X
DOI: https://doi.org/10.1109/EMBC.2018.8513548
Self-archived copy’s web address: https://arxiv.org/pdf/1811.02874
Therapeutic ultrasound is an investigational modality which could potentially be used for minimally invasive treatment of prostate cancer. Computational simulations were used to study the effect of natural physiological variations in tissue parameters on the efficacy of therapeutic ultrasound treatment in the prostate. The simulations were conducted on a clinical ultrasound therapy system using patient computed tomography (CT) data. The values of attenuation, perfusion, specific heat capacity and thermal conductivity were changed within their biological ranges to determine their effect on peak temperature andthermal dose volume. Increased attenuation was found to have the biggest effect on peak temperature with a 6.9%rise. The smallest effect was seen with perfusion with ±0.2% variation in peak temperature. Thermal dose was mostly affected by specific heat capacity which showed a 20.7% increase in volume with reduced heat capacity. Thermal conductivity had the smallest effect on thermal dose with up to 2.1% increase in the volume with reduced thermal conductivity. These results can be used to estimate the interpatient variation during the therapeutic ultrasound treatment of the prostate.
