Imaging is useful to confirm the diagnosis of coronary artery disease and to guide therapy in patients with an intermediate pretest likelihood of disease. This chapter gives an overview of the indications, special features, and diagnostic performance of different functional imaging modalities in the detection of myocardial ischaemia. Computed tomography and invasive coronary angiography can visualize coronary stenosis at high resolution and reliably rule out the presence of significant coronary artery disease. However, evaluation of the haemodynamic significance of coronary artery disease is difficult based on anatomy alone. Therefore, demonstration of myocardial ischaemia with the use of stress echocardiography, single-photon emission tomography, positron emission tomography, and cardiovascular magnetic resonance imaging is important to identify patients who can benefit from revascularization.