A2 Refereed review article in a scientific journal
Exhaled breath analysis in the diagnosis of head and neck cancer
Authors: Antti A. Mäkitie, Alhadi Almangush, Omar Youssef, Markus Metsälä, Suvi Silén, Iain J. Nixon, Missak Haigentz Jr., Juan P. Rodrigo, Nabil F. Saba, Vincent Vander Poorten, Alfio Ferlito
Publisher: WILEY
Publication year: 2019
Journal: Head and Neck
Journal name in source: HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
Journal acronym: HEAD NECK-J SCI SPEC
Volume: 42
First page : 787
Last page: 793
Number of pages: 7
ISSN: 1043-3074
eISSN: 1097-0347
DOI: https://doi.org/10.1002/hed.26043(external)
Abstract
Head and neck cancer (HNC) comprises a heterogeneous group of upper aerodigestive tract malignant neoplasms, the most frequent of which is squamous cell carcinoma. HNC forms the eighth most common cancer type and the incidence is increasing. However, survival has improved only moderately during the past decades. Currently, early diagnosis remains the mainstay for improving treatment outcomes in this patient population. Unfortunately, screening methods to allow early detection of HNC are not yet established. Therefore, many cases are still diagnosed at advanced stage, compromising outcomes. Exhaled breath analysis (EBA) is a diagnostic tool that has been recently introduced for many cancers. Breath analysis is non-invasive, cost-effective, time-saving, and can potentially be applied for cancer screening. Here, we provide a summary of the accumulated evidence on the feasibility of EBA in the diagnosis of HNC.
Head and neck cancer (HNC) comprises a heterogeneous group of upper aerodigestive tract malignant neoplasms, the most frequent of which is squamous cell carcinoma. HNC forms the eighth most common cancer type and the incidence is increasing. However, survival has improved only moderately during the past decades. Currently, early diagnosis remains the mainstay for improving treatment outcomes in this patient population. Unfortunately, screening methods to allow early detection of HNC are not yet established. Therefore, many cases are still diagnosed at advanced stage, compromising outcomes. Exhaled breath analysis (EBA) is a diagnostic tool that has been recently introduced for many cancers. Breath analysis is non-invasive, cost-effective, time-saving, and can potentially be applied for cancer screening. Here, we provide a summary of the accumulated evidence on the feasibility of EBA in the diagnosis of HNC.
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