For more than 30 years, studies highlighting the prognostic accuracy of the self-measured home blood pressure in populations and patients have paved the way for the widespread clinical application of this approach. Blood pressure self-measurement offers several of the well-recognized advantages of the more complex approach of ambulatory blood pressure monitoring. The home blood pressure outperforms the office blood pressure in the prediction of death and cardiovascular complications. Cross-classification of patients based on office and home blood pressure refines risk stratification. This chapter makes the point that self-measurement of the blood pressure at home is required to stop the hypertension epidemic and later adverse cardiovascular events.