Numerous factors need to be considered when defining an optimal home blood pressure measurement schedule, including the number, interval, and timing of readings. Overall, data from cross-sectional and prospective studies suggest that the predictive accuracy of home blood pressure increases with the number of measurements. Most of the benefit in increased accuracy is achieved already during the initial 3–4 measurement days when duplicate measurements are performed in the morning and evening. No good evidence exists that measurements performed on the first day of measurements need to be discarded, particularly when 7 days of measurements are used. The recommendations of the current hypertension guidelines on the schedule of home blood pressure measurement (duplicate measurements in the morning and evening on ≥3 days) agree relatively well with each other and the existing literature. Additional research and collaboration is needed to create a uniform international recommendation on the optimal schedule of home blood pressure measurement.