A2 Refereed review article in a scientific journal
The Microbiota and Malnutrition: Impact of Nutritional Status During Early Life
Authors: Carlos Gómez-Gallego, Izaskun García-Mantrana, Cecilia Martínez-Costa, Seppo Salminen, Erika Isolauri, M. Carmen Collado
Publisher: Annual Reviews Inc.
Publication year: 2019
Journal: Annual Review of Nutrition
Journal acronym: ANNU REV NUTR
Volume: 39
First page : 267
Last page: 290
Number of pages: 24
ISSN: 0199-9885
eISSN: 1545-4312
DOI: https://doi.org/10.1146/annurev-nutr-082117-051716
Abstract
According to the developmental origins of health and disease hypothesis, our health is determined by events experienced in utero and during early infancy. Indeed, both our prenatal and postnatal nutrition conditions have an impact on the initial architecture and activity of our microbiota. Recent evidence has underlined the importance of the composition of the early gut microbiota in relation to malnutrition, whether it be undernutrition or overnutrition, that is, in terms of both stunted and overweight development. It remains unclear how early microbial contact is linked to the risk of disease, as well as whether alterations in the microbiome underlie the pathogenesis of malnutrition or are merely the end result of it, which indicates that the question of causalitymust urgently be answered. This review provides information on the complex interaction between the microbiota and nutrition during the first 1,000 days of life, taking into account the impact of both undernutrition and overnutrition on the microbiota and on infants' health outcomes in the short- and long-term.
According to the developmental origins of health and disease hypothesis, our health is determined by events experienced in utero and during early infancy. Indeed, both our prenatal and postnatal nutrition conditions have an impact on the initial architecture and activity of our microbiota. Recent evidence has underlined the importance of the composition of the early gut microbiota in relation to malnutrition, whether it be undernutrition or overnutrition, that is, in terms of both stunted and overweight development. It remains unclear how early microbial contact is linked to the risk of disease, as well as whether alterations in the microbiome underlie the pathogenesis of malnutrition or are merely the end result of it, which indicates that the question of causalitymust urgently be answered. This review provides information on the complex interaction between the microbiota and nutrition during the first 1,000 days of life, taking into account the impact of both undernutrition and overnutrition on the microbiota and on infants' health outcomes in the short- and long-term.
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