A3 Vertaisarvioitu kirjan tai muun kokoomateoksen osa
X-ray crystallography in structure-function characterization of therapeutic enzymes
Tekijät: Anastassios C. Papageorgiou
Toimittaja: Nikolaos Labrou
Kustantaja: Springer New York LLC
Julkaisuvuosi: 2019
Kokoomateoksen nimi: Therapeutic Enzymes: Function and Clinical Implications
Sarjan nimi: Advances in Experimental Medicine and Biology
Vuosikerta: 1148
Aloitussivu: 81
Lopetussivu: 103
Sivujen määrä: 23
ISBN: 978-981-13-7708-2
eISBN: 978-981-13-7709-9
ISSN: 0065-2598
DOI: https://doi.org/10.1007/978-981-13-7709-9_4
Enzymesare key biological macromolecules that support life by accelerating theconversion of target molecules to desired products in many biochemical reactions. Enzymes are characterized by high affinity, specificity and great catalytic efficiency. Owing to their unique characteristics, enzymes have attracted significant attention for use in therapeutic settings as a distinct class of drugs different from other types of medicines. Enzyme-based therapies are currently in use for the treatmentof a wide range of diseases, including leukemia, metabolic disorders, inflammation and cardiovascular disease. However, several challenges, such as immunogenicity and stability, remain. X-ray crystallography has provided key structural insights into the understanding of the molecularbasis of diseases and development of enzyme-based therapies. Here, the role of X-ray crystallography in the development of therapeutic enzymes is examined and several examples are provided.