A3 Book chapter

X-ray crystallography in structure-function characterization of therapeutic enzymes




List of Authors: Anastassios C. Papageorgiou

Publisher: Springer New York LLC

Publication year: 2019

Book title *: Therapeutic Enzymes: Function and Clinical Implications

Title of series: Advances in Experimental Medicine and Biology

Volume number: 1148

Number of pages: 23

ISBN: 978-981-13-7708-2

eISBN: 978-981-13-7709-9

ISSN: 0065-2598

DOI: http://dx.doi.org/10.1007/978-981-13-7709-9_4


Abstract

Enzymesare key biological macromolecules that support life by accelerating theconversion of target molecules to desired products in many biochemical reactions. Enzymes are characterized by high affinity, specificity and great catalytic efficiency. Owing to their unique characteristics, enzymes have attracted significant attention for use in therapeutic settings as a distinct class of drugs different from other types of medicines. Enzyme-based therapies are currently in use for the treatmentof a wide range of diseases, including leukemia, metabolic disorders, inflammation and cardiovascular disease. However, several challenges, such as immunogenicity and stability, remain. X-ray crystallography has provided key structural insights into the understanding of the molecularbasis of diseases and development of enzyme-based therapies. Here, the role of X-ray crystallography in the development of therapeutic enzymes is examined and several examples are provided.


Last updated on 2021-24-06 at 09:09