A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Early probiotic supplementation and the risk of celiac disease in children at genetic risk
Tekijät: Ulla Uusitalo , Carin Andren Aronsson , Xiang Liu, Kalle Kurppa, Jimin Yang, Edwin Liu, Jennifer Skidmore, Christiane Winkler, Marian J. Rewers, William A. Hagopian, Jin-Xiong She, Jorma Toppari, Anette-G. Ziegler, Beena Akolkar, Jill M. Norris, Suvi M. Virtanen, Jeffrey P. Krischer, Daniel Agardh; on behalf of the TEDDY Study Group
Kustantaja: MDPI AG
Julkaisuvuosi: 2019
Journal: Nutrients
Tietokannassa oleva lehden nimi: Nutrients
Vuosikerta: 11
Numero: 8
Sivujen määrä: 14
ISSN: 2072-6643
eISSN: 2072-6643
DOI: https://doi.org/10.3390/nu11081790
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/42554102
Probiotics are linked to positive regulatory effects on the immune
system. The aim of the study was to examine the association between the
exposure of probiotics via dietary supplements or via infant formula by
the age of 1 year and the development of celiac disease autoimmunity
(CDA) and celiac disease among a cohort of 6520 genetically susceptible
children. Use of probiotics during the first year of life was reported
by 1460 children. Time-to-event analysis was used to examine the
associations. Overall exposure of probiotics during the first year of
life was not associated with either CDA (n = 1212) (HR 1.15; 95%CI 0.99, 1.35; p = 0.07) or celiac disease (n = 455) (HR 1.11; 95%CI 0.86, 1.43; p
= 0.43) when adjusting for known risk factors. Intake of probiotic
dietary supplements, however, was associated with a slightly increased
risk of CDA (HR 1.18; 95%CI 1.00, 1.40; p
= 0.043) compared to children who did not get probiotics. It was
concluded that the overall exposure of probiotics during the first year
of life was not associated with CDA or celiac disease in children at
genetic risk.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
