A1 Refereed original research article in a scientific journal
Evolution of microglial activation in ischaemic core and pen-infarct regions after stroke: A PET study with the TSPO molecular imaging biomarker [C-11]vinpocetine
Authors: Gulyas B, Toth M, Schain M, Airaksinen A, Vas A, Kostulas K, Lindstrom P, Hillert J, Halldin C
Publisher: ELSEVIER SCIENCE BV
Publication year: 2012
Journal: Journal of the Neurological Sciences
Journal name in source: JOURNAL OF THE NEUROLOGICAL SCIENCES
Journal acronym: J NEUROL SCI
Volume: 320
Issue: 1-2
First page : 110
Last page: 117
Number of pages: 8
ISSN: 0022-510X
DOI: https://doi.org/10.1016/j.jns.2012.06.026
Abstract
Although there is increasing evidence for microglial activation after an ischaemic stroke in the infarct core and the peri-infarct region, the "evolution" of the process in stroke patients is poorly known. Using PET and [C-11]vinpocetine, we measured the regional changes of TSPO in the brain of nine ischaemic stroke patients up to 14 weeks after the insult. Already a week after stroke there was an increased radioligand uptake, indicating the up-regulation of TSPO and the presence of activated microglia, in both the ischaemic core and the pen-infarct zone. This increased activation showed a steady decrease with post stroke time. The proportion between %SUV values in the pen-infarct zone and the ischaemic core increased with time. There were no time-dependent TSPO activity changes in other regions, not affected directly by the stroke. The present observations demonstrate that increased regional microglia activation, as a consequence of stroke, can be visualised with PET, using the TSPO molecular imaging biomarker [C-11]vinpocetine. The evolution of this microglial activation shows a time dependent decrease the gradient of which is different between the pen-infarct zone and the ischaemic core. The findings indicate an increased microglial activation in the pen-stroke region for several weeks after the insult. (c) 2012 Elsevier B.V. All rights reserved.
Although there is increasing evidence for microglial activation after an ischaemic stroke in the infarct core and the peri-infarct region, the "evolution" of the process in stroke patients is poorly known. Using PET and [C-11]vinpocetine, we measured the regional changes of TSPO in the brain of nine ischaemic stroke patients up to 14 weeks after the insult. Already a week after stroke there was an increased radioligand uptake, indicating the up-regulation of TSPO and the presence of activated microglia, in both the ischaemic core and the pen-infarct zone. This increased activation showed a steady decrease with post stroke time. The proportion between %SUV values in the pen-infarct zone and the ischaemic core increased with time. There were no time-dependent TSPO activity changes in other regions, not affected directly by the stroke. The present observations demonstrate that increased regional microglia activation, as a consequence of stroke, can be visualised with PET, using the TSPO molecular imaging biomarker [C-11]vinpocetine. The evolution of this microglial activation shows a time dependent decrease the gradient of which is different between the pen-infarct zone and the ischaemic core. The findings indicate an increased microglial activation in the pen-stroke region for several weeks after the insult. (c) 2012 Elsevier B.V. All rights reserved.
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