B2 Book chapter

Kinetic Modelling and Extraction of Metabolic Parameters

List of Authors: Hans Herzog, Hidehiro Iida, Liliana Calderia

Place: Cambridge, UK

Publication year: 2019

Book title *: Hybrid MR-PET Imaging: Systems, Methods and Applications

Title of series: New Developments in NMR

Number of pages: 10

ISBN: 978-1-78801-074-0

eISBN: 978-1-78801-683-4

ISSN: 2044-253X

DOI: http://dx.doi.org/10.1039/9781788013062-00183


Using molecules radiolabelled with positron emitters, positron emission tomography (PET) imaging provides information relating to a multitude of physiological and metabolic functions. Whereas primary PET images give a qualitative insight into these functions, when PET images are combined with data of the time course of the PET radiopharmaceutical in the blood, in an appropriate biological model, the extraction of quantified parameters of the observed function becomes possible. This chapter gives an introduction into kinetic modelling used with PET and the related mathematical procedures. Additionally, some basic and often used applications are described and are followed by an overview of the application of kinetic modelling in the case of MR-PET.

Last updated on 2021-24-06 at 10:42