NCOA4-RET and TRIM27-RET are Characteristic Gene Fusions in Salivary Intraductal Carcinoma, Including Invasive and Metastatic Tumors: Is "intraductal" Correct?

: Alena Skálová, Nikola Ptáková, Thalita Santana, Abbas Agaimy, Stephan Ihrler, Emmanuelle Uro-Coste,
Lester D.R Thompson, Justin A. Bishop, Martina Baněčkova, Niels J. Rupp, Patrizia Morbini, Stefano de Sanctis,
Marco Schiavo-Lena, Tomas Vanecek, Michal Michal, Ilmo Leivo

Publisher: Lippincott Williams and Wilkins

: 2019

: American Journal of Surgical Pathology

: 43

: 10

: 1303

: 1313

: 1532-0979

DOI: https://doi.org/10.1097/PAS.0000000000001301

Intraductal carcinoma (IC) is the new WHO designation for tumors previously encompassed by “low-grade cribriform cystadenocarcinoma” and “low-grade salivary duct carcinoma.” The relationship of IC to salivary duct carcinoma (SDC) is controversial, even though they are considered to be distinct entities. IC is a rare
low-grade malignant salivary gland neoplasm with histopathological features reminiscent of atypical ductal hyperplasia or ductal tumors are separate malignant salivary tumor entities. The presence of tumor-type–specific NCOA4-RET or TRIM27-RET translocations in a subset of widely invasive carcinomas with intercalated duct-like immunoprofiles suggests that a recharacterization of IC including its redesignation as “intercalated duct carcinoma, invasive or noninvasive” may be appropriate.