A2 Review article in a scientific journal

Host poly(ADP-ribose) polymerases (PARPs) in acute and chronic bacterial infections

List of Authors: Moona Miettinen, Madhukar Vedanthama, Arto T. Pulliainen

Publisher: Elsevier Masson SAS

Publication year: 2019

Journal: Microbes and Infection

Journal name in source: Microbes and Infection

Volume number: 21

Issue number: 10

Number of pages: 9

ISSN: 1286-4579

eISSN: 1769-714X

DOI: http://dx.doi.org/10.1016/j.micinf.2019.06.002


ADP-ribosylation is a reversible post-translational modification, which
alters protein activity, localization, interactome or stability,
leading to perturbation of cell signaling. This review summarizes the
emerging data indicating that host cell ADP-ribosylating enzymes,
poly(ADP-ribose) polymerases (PARPs), influence the course of a
bacterial infection, in parallel to ADP-ribosylating bacterial toxins.
Host cell PARP targeting could be an efficient therapeutic approach to
treat certain bacterial infections, possibly by repurposing the approved
or clinical trial PARP inhibitors developed for cancer therapy.

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Last updated on 2021-24-06 at 09:02