A1 Journal article – refereed

68Ga-DOTA-E[c(RGDfK)]2 Positron Emission Tomography Imaging of SHARPIN-Regulated Integrin Activity in Mice




List of Authors: Riikka Siitonen, Emilia Peuhu, Anu K Autio, Heidi Liljenbäck, Elina Mattila, Olli Metsälä, Meeri Käkelä, Tiina Saanijoki, Ingrid Dijkgraaf, Sirpa Jalkanen, Johanna Ivaska, Anne Roivainen

Publication year: 2019

Journal: Journal of Nuclear Medicine

Journal name in source: Journal of nuclear medicine : official publication, Society of Nuclear Medicine

Journal acronym: J Nucl Med

Volume number: 60

Issue number: 10

Number of pages: 8

ISSN: 0161-5505

eISSN: 1535-5667

DOI: http://dx.doi.org/10.2967/jnumed.118.222026


Abstract
Sharpincpdm mice demonstrated increased integrin activity and vascularization in B16-F10-luc melanoma tumors, as demonstrated by RGD-based in vivo PET imaging. These data indicate that SHARPIN, a protein previously associated with increased cancer growth and metastasis, may also have important regulatory roles in controlling the tumor microenvironment.

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Last updated on 2021-24-06 at 09:38