A1 Journal article – refereed

L1TD1 - a prognostic marker for colon cancer




List of Authors: Deepankar Chakroborty, Maheswara Reddy Emani, Riku Klén, Camilla Böckelman, Jaana Hagström, Caj Haglund, Ari Ristimäki, Riitta Lahesmaa, Laura L. Elo

Publisher: BMC Cancer

Publication year: 2019

Journal: BMC Cancer

Volume number: 19

Number of pages: 9

ISSN: 1471-2407

eISSN: 1471-2407

DOI: http://dx.doi.org/10.1186/s12885-019-5952-2


Abstract
Background

Prognostic markers specific to a particular cancer type can assist in the evaluation of survival probability of patients and help clinicians to assess the available treatment modalities.

Methods

Gene expression data was analyzed from three independent colon cancer microarray gene expression data sets (N = 1052). Survival analysis was performed for the three data sets, stratified by the expression level of the LINE-1 type transposase domain containing 1 (L1TD1). Correlation analysis was performed to investigate the role of the interactome of L1TD1 in colon cancer patients.

Results

We found L1TD1 as a novel positive prognostic marker for colon cancer. Increased expression of L1TD1 associated with longer disease-free survival in all the three data sets. Our results were in contrast to a previous study on medulloblastoma, where high expression of L1TD1 was linked with poor prognosis. Notably, in medulloblastoma L1TD1 was co-expressed with its interaction partners, whereas our analysis revealed lack of co-expression of L1TD1 with its interaction partners in colon cancer.

Conclusions

Our results identify increased expression of L1TD1 as a prognostic marker predicting longer disease-free survival in colon cancer patients.


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Last updated on 2021-13-07 at 14:37