A1 Refereed original research article in a scientific journal
MMP-10 and TIMP-1 as indicators of severe sepsis in adult hematological patients with febrile neutropenia
Authors: Stefan Becker, Sini Korpelainen, Miika Arvonen, Sari Hämäläinen, Esa Jantunen, Marika Lappalainen, Kari Pulkki, Pekka Riikonen, Auni Juutilainen
Publisher: TAYLOR & FRANCIS LTD
Publication year: 2019
Journal: Leukemia and Lymphoma
Journal name in source: LEUKEMIA & LYMPHOMA
Journal acronym: LEUKEMIA LYMPHOMA
Volume: 60
Issue: 12
First page : 3036
Last page: 3043
Number of pages: 8
ISSN: 1042-8194
DOI: https://doi.org/10.1080/10428194.2019.1617859
Abstract
Commonly used indicators of sepsis are nonspecific and insufficient for predicting the course of febrile neutropenia (FN) in hematological patients. We analyzed data from 91 adult FN patients who received intensive chemotherapy for acute myeloid leukemia or autologous stem cell transplantation. Compared to patients with non-severe sepsis, patients with severe sepsis had significantly higher serum levels of tissue inhibitor of metalloproteinases-1 on the day of first occurrence of fever (day 0: 172 vs. 112 mu g/L, p= .002) and for the two following days (day 1: 219 vs. 128 mu g/L, p< .001; day 2: 443 vs. 128 mu g/L, p= .001), and significantly higher serum levels of matrix metalloproteinase-10 on day 1 (1975 vs. 876 ng/L, p= .001) and day 2 (2020 vs. 841 ng/L, p< .001). We conclude that the measurement of these biomarkers may be useful in predicting the severity of sepsis in FN patients.
Commonly used indicators of sepsis are nonspecific and insufficient for predicting the course of febrile neutropenia (FN) in hematological patients. We analyzed data from 91 adult FN patients who received intensive chemotherapy for acute myeloid leukemia or autologous stem cell transplantation. Compared to patients with non-severe sepsis, patients with severe sepsis had significantly higher serum levels of tissue inhibitor of metalloproteinases-1 on the day of first occurrence of fever (day 0: 172 vs. 112 mu g/L, p= .002) and for the two following days (day 1: 219 vs. 128 mu g/L, p< .001; day 2: 443 vs. 128 mu g/L, p= .001), and significantly higher serum levels of matrix metalloproteinase-10 on day 1 (1975 vs. 876 ng/L, p= .001) and day 2 (2020 vs. 841 ng/L, p< .001). We conclude that the measurement of these biomarkers may be useful in predicting the severity of sepsis in FN patients.
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