A1 Journal article – refereed

Validating 10-joint juvenile arthritis disease activity score cut-offs for disease activity levels in non-systemic juvenile idiopathic arthritis




List of Authors: Maria Backström, Pirjo Tynjälä, Kristiina Aalto, Minna-Maija Grönlund, Heikki Ylijoki, Anne Putto-Laurila, Johanna Kärki, Paula Keskitalo, Sirja Sard, Heini Pohjankoski, Maiju Hietanen, Silke Witter, Helena Lehto, Eliisa Löyttyniemi, Paula Vähäsalo

Publisher: BMJ Publishing Group

Publication year: 2019

Journal: RMD Open

Journal name in source: RMD Open

Volume number: 5

Issue number: 1

Number of pages: 9

ISSN: 2056-5933

eISSN: 2056-5933

DOI: http://dx.doi.org/10.1136/rmdopen-2018-000888


Abstract

Objectives
To validate cut-offs of the Juvenile Arthritis Disease Activity Score
10 (JADAS10) and clinical JADAS10 (cJADAS10) and to compare them with
other patient cohorts.

Methods
In a national multicentre study, cross-sectional data on recent visits
of 337 non-systemic patients with juvenile idiopathic arthritis (JIA)
were collected from nine paediatric outpatient units. The cut-offs were
tested with receiver operating characteristic curve-based methods, and
too high, too low and correct classification rates (CCRs) were
calculated.

Results
Our earlier presented JADAS10 cut-offs seemed feasible based on the
CCRs, but the cut-off values between low disease activity (LDA) and
moderate disease activity (MDA) were adjusted. When JADAS10 cut-offs for
clinically inactive disease (CID) were increased to 1.5 for patients
with oligoarticular disease and 2.7 for patients with polyarticular
disease, as recently suggested in a large multinational register study,
altogether 11 patients classified as CID by the cut-off had one active
joint. We suggest JADAS10 cut-off values for
oligoarticular/polyarticular disease to be in CID: 0.0–0.5/0.0–0.7, LDA:
0.6–3.8/0.8–5.1 and MDA: >3.8/5.1. Suitable cJADAS10 cut-offs are
the same as JADAS10 cut-offs in oligoarticular disease. In polyarticular
disease, cJADAS10 cut-offs are 0–0.7 for CID, 0.8–5.0 for LDA and
>5.0 for MDA.

Conclusion
International consensus on JADAS cut-off values is needed, and such a
cut-off for CID should preferably exclude patients with active joints in
the CID group.


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Last updated on 2021-24-06 at 11:46