A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Increased susceptibility to pertussis in adults at childbearing age as determined by comparative seroprevalence study, China 2010–2016
Tekijät: Zhang Y., Chen Z., Zhao J., Zhang N., Chen N., Zhang J., Li S., He Q.
Kustantaja: W.B. Saunders Ltd
Julkaisuvuosi: 2019
Journal: Journal of Infection
Tietokannassa oleva lehden nimi: Journal of Infection
Vuosikerta: 79
Numero: 1
Aloitussivu: 1
Lopetussivu: 6
Sivujen määrä: 6
ISSN: 0163-4453
DOI: https://doi.org/10.1016/j.jinf.2019.04.011
Objectives: This study was aimed to determine pertussis specific serum PT-IgG antibodies in healthy individuals during 2010 and 2015/2016 in Beijing, China.
Methods: A total of 3884 healthy individuals were included: 3058 aged 3–69 years randomly selected from an epidemiological survey conducted in 2010, and 826 aged 20–39 years selected from those who attended an annual medical examination in 2015/2016. Serum PT-IgG antibodies were determined using the Serion/Virion ELISA kits.
Results: Of 3058 subjects in 2010, 167 (5.5%) and 39 (1.3%) subjects had PT-IgG antibodies ≥40 IU/ml and ≥100 IU/ml, respectively. No differences were observed among different age groups. Altogether, 26.2% had undetectable PT-IgG antibodies (<5 IU/ml), and the highest undetectable rate of 56.8% was found in children aged 3–5 years. When the age group of 20–39 years was compared between the two periods, no difference was found in seroprevalence of PT-IgG antibodies ≥ 40 IU/ml (5.1% vs. 4.0%). However, an undetectable rate of PT-IgG antibodies was significantly higher in 2015/2016 than that in 2010 (57.4% vs. 29.1%, p < 0.001).
Conclusions: Our results showed that about 5% of individuals had PT-IgG antibodies indicative of a recent infection, and adults at childbearing age have an increased risk to pertussis in China.