A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Modifying drug release and tablet properties of starch acetate tablets by dry powder agglomeration
Tekijät: Maki R, Suihko E, Rost S, Heiskanen M, Murtomaa M, Lehto VP, Ketolainen J
Kustantaja: JOHN WILEY & SONS INC
Julkaisuvuosi: 2007
Lehti:: Journal of Pharmaceutical Sciences
Tietokannassa oleva lehden nimi: JOURNAL OF PHARMACEUTICAL SCIENCES
Lehden akronyymi: J PHARM SCI-US
Vuosikerta: 96
Numero: 2
Aloitussivu: 438
Lopetussivu: 447
Sivujen määrä: 10
ISSN: 0022-3549
DOI: https://doi.org/10.1002/jps.20784
Tiivistelmä
In this study three model drugs (N-acetyl-D-glucosamine (NAG), anhydrous caffeine, and propranolol hydrochloride) were agglomerated with starch acetate (SA) by mixing the binary powders on a stainless steel (SS) plate. Agglomeration was induced by triboelectrification of the particles during mixing, and it was evaluated as a method to achieve controlled drug release rate. These agglomerates, mixed with different amounts of a disintegrant, were compressed into tablets whose dissolution characteristics were determined. Triboelectric measurements showed that when the drugs were in contact with SS, charges of the opposite polarity were generated to SA (+) and caffeine and NAG (-) promoting adhesion. Instead, propranolol HCl was charged with the same polarity as SA. SEM micrographs showed that smaller caffeine particles, in spite of their larger negative charge, agglomerated less efficiently with SA than larger NAG particles. This emphasizes the importance of particle size in the agglomeration process. Propranolol HCl did not form agglomerates with SA since their particle sizes and charges were identical. As a result, agglomeration of powders prior to tablet compression allows for modification and control of the release rate of the drugs from the SA matrix tablets as well as the tensile strength of the tablets. (c) 2006 Wiley-Liss, Inc.
In this study three model drugs (N-acetyl-D-glucosamine (NAG), anhydrous caffeine, and propranolol hydrochloride) were agglomerated with starch acetate (SA) by mixing the binary powders on a stainless steel (SS) plate. Agglomeration was induced by triboelectrification of the particles during mixing, and it was evaluated as a method to achieve controlled drug release rate. These agglomerates, mixed with different amounts of a disintegrant, were compressed into tablets whose dissolution characteristics were determined. Triboelectric measurements showed that when the drugs were in contact with SS, charges of the opposite polarity were generated to SA (+) and caffeine and NAG (-) promoting adhesion. Instead, propranolol HCl was charged with the same polarity as SA. SEM micrographs showed that smaller caffeine particles, in spite of their larger negative charge, agglomerated less efficiently with SA than larger NAG particles. This emphasizes the importance of particle size in the agglomeration process. Propranolol HCl did not form agglomerates with SA since their particle sizes and charges were identical. As a result, agglomeration of powders prior to tablet compression allows for modification and control of the release rate of the drugs from the SA matrix tablets as well as the tensile strength of the tablets. (c) 2006 Wiley-Liss, Inc.
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