Strong persistent luminescence (PeL) from silica bodies was obtained, for the first time, by sintering silica powder mixed with PeL SrAl2O4:Eu2+,Dy3+ microparticles (MPs). We show that it is not possible to prepare transparent PeL silica glass due to the decomposition of the MPs, which occurs already at 1450 °C. The MPs decomposition was associated with the precipitation of Sr3Al10SiO20 phase when sintering up to 1650 °C and of SrAl2Si2O8 when sintering between 1650 and 1750 °C. Cristobalite was found to also precipitate when sintering for 10 min but has no impact on the PeL of the bodies.