Fabrication of a multifunctional nano-in-micro drug delivery platform by microfluidic templated encapsulation of porous silicon in polymer matrix - UTU Research Portal

A1 Refereed original research article in a scientific journal

Fabrication of a multifunctional nano-in-micro drug delivery platform by microfluidic templated encapsulation of porous silicon in polymer matrix

Authors: Hongbo Zhang, Dongfei Liu, Mohammad-Ali Shahbazi, Ermei Mäkilä, Bárbara Herranz-Blanco, Jarno Salonen, Jouni Hirvonen, Hélder A. Santos

Publisher: Wiley-VCH Verlag

Publication year: 2014

Journal: Advanced Materials

Journal name in source: Advanced Materials

Volume: 26

Issue: 26

First page : 4497

Last page: 4503

Number of pages: 8

ISSN: 1521-4095

DOI: https://doi.org/10.1002/adma.201400953

Web address : http://api.elsevier.com/content/abstract/scopus_id:84904188661

Abstract

A multifunctional nano-in-micro drug delivery platform is developed by conjugating the porous silicon nanoparticles with mucoadhesive polymers and subsequent encapsulation into a pH-responsive polymer using microfluidics. The multistage platform shows monodisperse size distribution and pH-responsive payload release, and the released nanoparticles are mucoadhesive. Moreover, this platform is capable of simultaneously loading and releasing multidrugs with distinct properties. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.