A1 Refereed original research article in a scientific journal
Microfluidic assembly of multistage porous silicon-lipid vesicles for controlled drug release
Authors: Bárbara Herranz-Blanco, Laura R. Arriaga, Ermei Mäkilä, Alexandra Correia, Neha Shrestha, Sabiruddin Mirza, David A. Weitz, Jarno Salonen, Jouni Hirvonen, Hélder A. Santos
Publisher: ROYAL SOC CHEMISTRY
Publication year: 2014
Journal: Lab on a Chip
Journal name in source: LAB ON A CHIP
Journal acronym: LAB CHIP
Volume: 14
Issue: 6
First page : 1083
Last page: 1086
Number of pages: 4
ISSN: 1473-0197
DOI: https://doi.org/10.1039/c3lc51260f
A reliable microfluidic platform for the generation of stable and monodisperse multistage drug delivery systems is reported. A glass-capillary flow-focusing droplet generation device was used to encapsulate thermally hydrocarbonized porous silicon (PSi) microparticles into the aqueous cores of double emulsion drops, yielding the formation of a multistage PSi-lipid vesicle. This composite system enables a large loading capacity for hydrophobic drugs.
