A1 Refereed original research article in a scientific journal

Microfluidic assembly of multistage porous silicon-lipid vesicles for controlled drug release




AuthorsBárbara Herranz-Blanco, Laura R. Arriaga, Ermei Mäkilä, Alexandra Correia, Neha Shrestha, Sabiruddin Mirza, David A. Weitz, Jarno Salonen, Jouni Hirvonen, Hélder A. Santos

PublisherROYAL SOC CHEMISTRY

Publication year2014

JournalLab on a Chip

Journal name in sourceLAB ON A CHIP

Journal acronymLAB CHIP

Volume14

Issue6

First page 1083

Last page1086

Number of pages4

ISSN1473-0197

DOIhttps://doi.org/10.1039/c3lc51260f(external)


Abstract

A reliable microfluidic platform for the generation of stable and monodisperse multistage drug delivery systems is reported. A glass-capillary flow-focusing droplet generation device was used to encapsulate thermally hydrocarbonized porous silicon (PSi) microparticles into the aqueous cores of double emulsion drops, yielding the formation of a multistage PSi-lipid vesicle. This composite system enables a large loading capacity for hydrophobic drugs.




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