Habitual sleep duration is associated with BMI and macronutrient intake and may be modified by CLOCK genetic variants - UTU Research Portal

A1 Refereed original research article in a scientific journal

Habitual sleep duration is associated with BMI and macronutrient intake and may be modified by CLOCK genetic variants

Authors: Dashti HS, Follis JL, Smith CE, Tanaka T, Cade BE, Gottlieb DJ, Hruby A, Jacques PF, Lamon-Fava S, Richardson K, Saxena R, Scheer FAJL, Kovanen L, Bartz TM, Perala MM, Jonsson A, Frazier-Wood AC, Kalafati IP, Mikkila V, Partonen T, Lemaitre RN, Lahti J, Hernandez DG, Toft U, Johnson WC, Kanoni S, Raitakari OT, Perola M, Psaty BM, Ferrucci L, Grarup N, Highland HM, Rallidis L, Kahonen M, Havulinna AS, Siscovick DS, Raikkonen K, Jorgensen T, Rotter JI, Deloukas P, Viikari JSA, Mozaffarian D, Linneberg A, Seppala I, Hansen T, Salomaa V, Gharib SA, Eriksson JG, Bandinelli S, Pedersen O, Rich SS, Dedoussis G, Lehtimaki T, Ordovaas JM

Publisher: AMER SOC NUTRITION-ASN

Publication year: 2015

Journal: American Journal of Clinical Nutrition

Journal name in source: AMERICAN JOURNAL OF CLINICAL NUTRITION

Journal acronym: AM J CLIN NUTR

Volume: 101

Issue: 1

First page : 135

Last page: 143

Number of pages: 9

ISSN: 0002-9165

DOI: https://doi.org/10.3945/ajcn.114.095026

Abstract

Conclusions: Our results indicate that longer habitual sleep duration is associated with lower BMI and age- and sex-specific favorable dietary behaviors. Differences in the relative intake of specific macronutrients associated with short sleep duration could, at least in part, explain previously reported associations between short sleep duration and chronic metabolic abnormalities. In addition, the influence of obesity-associated CLOCK variants on the association between sleep duration and macronutrient intake suggests that longer habitual sleep duration could ameliorate the genetic predisposition to obesity via a favorable dietary profile.