A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Impaired insulin sensitivity is associated with worsening cognition in HIV-infected patients

Julkaisun tekijät: Khuder SS, Chen SM, Letendre S, Marcotte T, Grant I, Franklin D, Rubin LH, Margolick JB, Jacobson LP, Sacktor N, D'Souza G, Stosor V, Lake JE, Rapocciolo G, McArthur JC, Dickens AM, Haughey NJ, Haughey NJ


Julkaisuvuosi: 2019

Journal: Neurology

Tietokannassa oleva lehden nimi: NEUROLOGY

Lehden akronyymi: NEUROLOGY

Volyymi: 92

Julkaisunumero: 12

Sivujen määrä: 10

ISSN: 0028-3878

eISSN: 1526-632X

DOI: http://dx.doi.org/10.1212/WNL.0000000000007125

Objective To determine the association of insulin sensitivity and metabolic status with declining cognition in HIV-infected individuals. Methods We conducted targeted clinical and metabolic measures in longitudinal plasma samples obtained from HIV-infected patients enrolled in the Central Nervous System HIV Anti-Retroviral Therapy Effects Research Study (CHARTER). Findings were validated with plasma samples from the Multicenter AIDS Cohort Study (MACS). Patients were grouped according to longitudinally and serially assessed cognitive performance as having stably normal or declining cognition. Results Patients with declining cognition exhibited baseline hyperinsulinemia and elevated plasma c-peptide levels with normal c-peptide/insulin ratios, suggesting that insulin production was increased, but insulin clearance was normal. The association of hyperinsulinemia with worsening cognition was further supported by low high-density lipoprotein (HDL), high low-density lipoprotein/HDL ratio, and elevated cholesterol/HDL ratio compared to patients with stably normal cognition. Conclusions These findings suggest that hyperinsulinemia and impaired insulin sensitivity are associated with cognitive decline in antiretroviral therapy-treated HIV-infected patients.

Last updated on 2021-24-06 at 09:32