Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1)

Loss of Primary Cilia Results in the Development of Cancer in the Murine Thyroid Gland




Julkaisun tekijät: Lee J, Yi S, Chang JY, Kim JT, Sul HJ, Park KC, Zhu XG, Cheng SY, Kero J, Kim J, Shong M

Kustantaja: KOREAN SOC MOLECULAR & CELLULAR BIOLOGY

Julkaisuvuosi: 2019

Journal: Molecules and Cells

Tietokannassa oleva lehden nimi: MOLECULES AND CELLS

Lehden akronyymi: MOL CELLS

Volyymi: 42

Julkaisunumero: 2

Sivujen määrä: 10

ISSN: 1016-8478

eISSN: 0219-1032

DOI: http://dx.doi.org/10.14348/molcells.2018.0430

Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/39917791


Tiivistelmä
Communications at the interface between the apical membrane of follicular cells and the follicular lumen are critical for the homeostasis of thyroid gland. Primary cilia at the apical membrane of thyroid follicular cells may sense follicular luminal environment and regulate follicular homeostasis, although their role in vivo remains to be determined. Here, mice devoid of primary cilia were generated by thyroid follicular epithelial cell-specific deletion of the gene encoding intraflagellar transport protein 88 (Ift88). Thyroid follicular cell-specific Ift88-deficient mice showed normal folliculogenesis and hormonogenesis; however, those older than 7 weeks showed irregularly dilated and destroyed follicles in the thyroid gland. With increasing age, follicular cells with malignant properties showing the characteristic nuclear features of human thyroid carcinomas formed papillary and solid proliferative nodules from degenerated thyroid follicles. Furthermore, malignant tumor cells manifested as tumor emboli in thyroid vessels. These findings suggest that loss-of-function of Ift88/primary cilia results in malignant transformation from degenerated thyroid follicles.

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Last updated on 2022-07-04 at 17:18