Toll-like Receptor 5 in Obesity: The Role of Gut Microbiota and Adipose Tissue Inflammation - UTU Research Portal

A1 Refereed original research article in a scientific journal

Toll-like Receptor 5 in Obesity: The Role of Gut Microbiota and Adipose Tissue Inflammation

Authors: Pekkala S, Munukka E, Kong LJ, Pollanen E, Autio R, Roos C, Wiklund P, Fischer-Posovszky P, Wabitsch M, Alen M, Huovinen P, Cheng SL

Publisher: WILEY-BLACKWELL

Publication year: 2015

Journal: Obesity

Journal name in source: OBESITY

Journal acronym: OBESITY

Volume: 23

Issue: 3

First page : 581

Last page: 590

Number of pages: 10

ISSN: 1930-7381

DOI: https://doi.org/10.1002/oby.20993

Abstract

ConclusionsThe in vivo findings suggest that flagellated Clostridium cluster XIV bacteria contribute to the development of obesity through distorted adipose tissue metabolism and inflammation. The in vitro studies in adipocytes show that the underlying mechanisms of the human findings may be due to flagellin-activated TLR5 signaling.