A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
From Mannose to Small Amphiphilic Polyol: Perfect Linearity Leads To Spontaneous Aggregation
Tekijät: Saloranta T, Peuronen A, Dieterich JM, Ruokolainen J, Lahtinen M, Leino R
Kustantaja: AMER CHEMICAL SOC
Julkaisuvuosi: 2016
Journal: Crystal Growth and Design
Tietokannassa oleva lehden nimi: CRYSTAL GROWTH & DESIGN
Lehden akronyymi: CRYST GROWTH DES
Vuosikerta: 16
Numero: 2
Aloitussivu: 655
Lopetussivu: 661
Sivujen määrä: 7
ISSN: 1528-7483
DOI: https://doi.org/10.1021/acs.cgd.5b01135
Tiivistelmä
Terminally unsaturated and diastereochemically pure polyol derived from D-mannose shows spontaneous aggregation behavior in water solution. In order to study and clarify this unforeseen phenomenon, a conformational study based on NMR spectroscopy combined with ab initio structure analysis using the COSMO-solvation model was pursued. The results, together with X-ray diffraction studies, suggest a low energy linear conformation for this particular substrate both in solid states and in solution. For such small-sized acyclic carbohydrate derivatives, the linear conformation appears to be a key prerequisite for the unusual molecular self-assembly reported herein.
Terminally unsaturated and diastereochemically pure polyol derived from D-mannose shows spontaneous aggregation behavior in water solution. In order to study and clarify this unforeseen phenomenon, a conformational study based on NMR spectroscopy combined with ab initio structure analysis using the COSMO-solvation model was pursued. The results, together with X-ray diffraction studies, suggest a low energy linear conformation for this particular substrate both in solid states and in solution. For such small-sized acyclic carbohydrate derivatives, the linear conformation appears to be a key prerequisite for the unusual molecular self-assembly reported herein.
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