A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
SOLUTION CONFORMATIONS AND HYDROLYTIC STABILITY OF 2 '-SUBSTITUTED AND 3'-SUBSTITUTED 2',3'-DIDEOXYRIBONUCLEOSIDES, INCLUDING SOME POTENTIAL INHIBITORS OF HUMAN-IMMUNODEFICIENCY-VIRUS
Tekijät: OKSMAN P, HAKALA H, ZAVGORODNY S, POLIANSKI M, AZHAYEV A, VANAERSCHOT A, HERDEWIJN P, LONNBERG H
Kustantaja: JOHN WILEY & SONS LTD
Julkaisuvuosi: 1992
Lehti:: Journal of Physical Organic Chemistry
Tietokannassa oleva lehden nimi: JOURNAL OF PHYSICAL ORGANIC CHEMISTRY
Lehden akronyymi: J PHYS ORG CHEM
Vuosikerta: 5
Numero: 11
Aloitussivu: 741
Lopetussivu: 747
Sivujen määrä: 7
ISSN: 0894-3230
DOI: https://doi.org/10.1002/poc.610051106
Tiivistelmä
Sugar ring conformations of a number of 2'- and 3'-substituted 2',3'-dieoxyribonudeosides were determined in (H2O)-H-2 by H-1 NMR spectroscopy. First-order rate constants for the cleavage of their N-glycosidic bond in aqueous acid were measured. The dependence of sugar ring conformation and hydrolytic stability on the polar nature of the 2'/3'-substitutent is discussed.
Sugar ring conformations of a number of 2'- and 3'-substituted 2',3'-dieoxyribonudeosides were determined in (H2O)-H-2 by H-1 NMR spectroscopy. First-order rate constants for the cleavage of their N-glycosidic bond in aqueous acid were measured. The dependence of sugar ring conformation and hydrolytic stability on the polar nature of the 2'/3'-substitutent is discussed.
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