A2 Refereed review article in a scientific journal
Tailoring of Proteostasis Networks with Heat Shock Factors
Authors: Joutsen Jenny, Sistonen Lea
Publisher: Cold Spring Harbor Laboratory Press
Publication year: 2019
Journal: Cold Spring Harbor Perspectives in Biology
Journal name in source: Cold Spring Harbor perspectives in biology
Journal acronym: Cold Spring Harb Perspect Biol
Volume: 11
Issue: 4
Number of pages: 17
ISSN: 1943-0264
eISSN: 1943-0264
DOI: https://doi.org/10.1101/cshperspect.a034066
Abstract
Heat shock factors (HSFs) are the main transcriptional regulators of the heat shock response and indispensable for maintaining cellular proteostasis. HSFs mediate their protective functions through diverse genetic programs, which are composed of genes encoding molecular chaperones and other genes crucial for cell survival. The mechanisms that are used to tailor HSF-driven proteostasis networks are not yet completely understood, but they likely comprise from distinct combinations of both genetic and proteomic determinants. In this review, we highlight the versatile HSF-mediated cellular functions that extend from cellular stress responses to various physiological and pathological processes, and we underline the key advancements that have been achieved in the field of HSF research during the last decade.
Heat shock factors (HSFs) are the main transcriptional regulators of the heat shock response and indispensable for maintaining cellular proteostasis. HSFs mediate their protective functions through diverse genetic programs, which are composed of genes encoding molecular chaperones and other genes crucial for cell survival. The mechanisms that are used to tailor HSF-driven proteostasis networks are not yet completely understood, but they likely comprise from distinct combinations of both genetic and proteomic determinants. In this review, we highlight the versatile HSF-mediated cellular functions that extend from cellular stress responses to various physiological and pathological processes, and we underline the key advancements that have been achieved in the field of HSF research during the last decade.
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