A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä

Refinement-based modeling of the ErbB signaling pathway




TekijätBogdan Iancu, Usman Sanwal, Cristian Gratie, Ion Petre

KustantajaElsevier Ltd.

Julkaisuvuosi2019

JournalComputers in Biology and Medicine

Vuosikerta106

Aloitussivu91

Lopetussivu96

Sivujen määrä6

ISSN0010-4825

eISSN1879-0534

DOIhttps://doi.org/10.1016/j.compbiomed.2019.01.016


Tiivistelmä

The construction of large scale biological models is a laborious task, which is often addressed by adopting iterative routines for model augmentation, adding certain details to an initial high level abstraction of the biological phenomenon of interest. Refitting a model at every step of its development is time consuming and computationally intensive. The concept of model refinement brings about an effective alternative by providing adequate parameter values that ensure the preservation of its quantitative fit at every refinement step. We demonstrate this approach by constructing the largest-ever refinement-based biomodel, consisting of 421 species and 928 reactions. We start from an already fit, relatively small literature model whose consistency we check formally. We then construct the final model through an algorithmic step-by-step refinement procedure that ensures the preservation of the model's fit.



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