A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
From genomes to functions in aquatic biology
Tekijät: Nikinmaa M, Rytkonen KT
Kustantaja: ELSEVIER SCIENCE BV
Julkaisuvuosi: 2012
Journal: Marine Genomics
Tietokannassa oleva lehden nimi: MARINE GENOMICS
Lehden akronyymi: MAR GENOM
Vuosikerta: 5
Aloitussivu: 1
Lopetussivu: 6
Sivujen määrä: 6
ISSN: 1874-7787
DOI: https://doi.org/10.1016/j.margen.2011.08.004
Tiivistelmä
In this paper we evaluate factors which should, in our opinion, be taken into account when genomic studies in aquatic organisms are extended to functions. Our first point is that genome-wide gene duplications characteristic of teleosts have enabled more rapid evolution in fish generally than usually in tetrapods. We further discuss factors that are pertinent when gene ontologies are used in animals with little earlier work combining genomic and functional data. We then review issues relating to transcription, especially transcription factor function and gene regulatory pathways. As the most important single factor affecting gene expression is translation, we emphasize the need to relate mRNA and protein level findings whenever functional inferences are made. We finish with considering the possible roles of functional genomics studies in aquatic environmental research. We have concentrated especially on fish, although many of the points made are common to all eukaryotes. (C) 2011 Elsevier B.V. All rights reserved.
In this paper we evaluate factors which should, in our opinion, be taken into account when genomic studies in aquatic organisms are extended to functions. Our first point is that genome-wide gene duplications characteristic of teleosts have enabled more rapid evolution in fish generally than usually in tetrapods. We further discuss factors that are pertinent when gene ontologies are used in animals with little earlier work combining genomic and functional data. We then review issues relating to transcription, especially transcription factor function and gene regulatory pathways. As the most important single factor affecting gene expression is translation, we emphasize the need to relate mRNA and protein level findings whenever functional inferences are made. We finish with considering the possible roles of functional genomics studies in aquatic environmental research. We have concentrated especially on fish, although many of the points made are common to all eukaryotes. (C) 2011 Elsevier B.V. All rights reserved.
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